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Unlocking New Levels of Output and Capacity for Key Subsurface Resources (UNLOCK)

Deadline: November 20, 2026

Opportunity Number: DE-FOA-0003630

Agency: Advanced Research Projects Agency Energy

Open Date: October 21, 2026

Close Date: November 20, 2026

Status: Posted

CFDA Numbers: 81.135

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Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)

Deadline: January 29, 2027

Opportunity Number: RFA-AI-28-012

Agency: National Institutes of Health

Open Date: October 20, 2026

Close Date: January 29, 2027

Status: Posted

CFDA Numbers: 93.310, 93.855

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National Resource Network for the Study of Human Auditory and Vestibular Disorders (U24 Clinical Trial Not Allowed)

Deadline: November 1, 2027

Opportunity Number: RFA-DC-28-001

Agency: National Institutes of Health

Open Date: October 20, 2026

Close Date: November 1, 2027

Status: Posted

CFDA Numbers: 93.173

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Coordinating Center for National Resource Network for the Study of Human Auditory and Vestibular Disorders (U24 Clinical Trial Not Allowed)

Deadline: March 5, 2027

Opportunity Number: RFA-DC-28-002

Agency: National Institutes of Health

Open Date: October 20, 2026

Close Date: March 5, 2027

Status: Posted

CFDA Numbers: 93.173

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Immune Tolerance Network (UM1 Clinical Trial Required)

Deadline: January 29, 2027

Opportunity Number: RFA-AI-28-005

Agency: National Institutes of Health

Open Date: October 20, 2026

Close Date: January 29, 2027

Status: Posted

CFDA Numbers: 93.855

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Pilot and Feasibility Studies in Preparation for Substance Use and HIV Prevention Intervention and Services Research Trials (R34 Clinical Trial Optional)

Deadline: July 16, 2029

Opportunity Number: PAR-28-093

Agency: National Institutes of Health

Open Date: October 19, 2026

Close Date: July 16, 2029

Status: Posted

CFDA Numbers: 93.681, 93.279, 93.310

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FY 2027 – 2029 Broad Agency Announcement (BAA), National Marine Fisheries Service

Deadline: September 30, 2028

Opportunity Number: NOAA-NMFS-FHQ-2027-33600

Agency: DOC NOAA - ERA Production

Open Date: October 16, 2026

Close Date: September 30, 2028

Status: Posted

CFDA Numbers: 11.015

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Centers for AIDS Research (CFAR) and Developmental Centers for AIDS Research (D-CFAR) (P30 Clinical Trial Not Allowed)

Deadline: May 25, 2029

Opportunity Number: PAR-28-090

Agency: National Institutes of Health

Open Date: October 16, 2026

Close Date: May 25, 2029

Status: Posted

CFDA Numbers: 93.847, 93.242, 93.396, 93.838, 93.866, 93.310, 93.837, 93.989, 93.307, 93.393, 93.840, 93.361, 93.121, 93.394, 93.839, 93.855, 93.279, 93.865, 93.233, 93.395

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NLM Institutional Grants for Research Training in Biomedical Informatics, Data Science, and AI (T15 Independent Clinical Trial Not Allowed)

Deadline: February 11, 2027

Opportunity Number: RFA-LM-28-001

Agency: National Institutes of Health

Open Date: October 16, 2026

Close Date: February 11, 2027

Status: Posted

CFDA Numbers: 93.242, 93.121, 93.398, 93.867, 93.279, 93.310, 93.855, 93.853, 93.173, 93.879

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Specialized Alcohol Research Centers (P50 Clinical trial Optional)

Deadline: January 27, 2027

Opportunity Number: RFA-AA-28-001

Agency: National Institutes of Health

Open Date: October 15, 2026

Close Date: January 27, 2027

Status: Posted

CFDA Numbers: 93.273

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Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)

Deadline: November 17, 2026

Opportunity Number: RFA-DK-27-122

Agency: National Institutes of Health

Open Date: October 15, 2026

Close Date: November 17, 2026

Status: Posted

CFDA Numbers: 93.847

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Assessing the Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R33 Clinical Trial Required)

Deadline: November 16, 2029

Opportunity Number: PAR-28-091

Agency: National Institutes of Health

Open Date: October 15, 2026

Close Date: November 16, 2029

Status: Posted

CFDA Numbers: 93.213, 93.473

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Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)

Deadline: October 11, 2029

Opportunity Number: PAR-28-014

Agency: National Institutes of Health

Open Date: October 14, 2026

Close Date: October 11, 2029

Status: Posted

CFDA Numbers: 93.113, 93.393

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Specialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2027, 2028, and 2029 (P50 Clinical Trial Required)

Deadline: September 25, 2029

Opportunity Number: PAR-28-022

Agency: National Institutes of Health

Open Date: October 14, 2026

Close Date: September 25, 2029

Status: Posted

CFDA Numbers: 93.121, 93.395

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NIH Research Program Projects (Parent P01 Clinical Trial Optional)

Deadline: May 25, 2029

Opportunity Number: PA-27-061

Agency: National Institutes of Health

Open Date: October 14, 2026

Close Date: May 25, 2029

Status: Posted

CFDA Numbers: 93.866, 93.279, 93.837, 93.839, 93.393, 93.838, 93.313, 93.395, 93.855, 93.394, 93.113, 93.233, 93.396, 93.840, 93.879, 93.307, 93.172, 93.273, 93.399

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Palliative Care Research Across the Lifespan: Leveraging the Palliative Care Consortium (R01 Clinical Trial Optional)

Deadline: November 5, 2029

Opportunity Number: PAR-27-090

Agency: National Institutes of Health

Open Date: October 14, 2026

Close Date: November 5, 2029

Status: Posted

CFDA Numbers: 93.361, 93.242, 93.865, 93.393, 93.853, 93.866, 93.307

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Collaborative Program Grant for Interdisciplinary Teams (RM1 Clinical Trial Optional)

Deadline: September 26, 2029

Opportunity Number: PAR-27-003

Agency: National Institutes of Health

Open Date: October 14, 2026

Close Date: September 26, 2029

Status: Posted

CFDA Numbers: 93.173, 93.866, 93.879, 93.473, 93.867, 93.279, 93.853, 93.846, 93.121, 93.855, 93.273, 93.172, 93.859

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Cooperative Agreement for affiliated Partner with Great Lakes-Northern Forest Cooperative Ecosystem Studies Unit

Deadline: November 14, 2026

Opportunity Number: G27AS00049

Agency: Geological Survey

Open Date: October 14, 2026

Close Date: November 14, 2026

Status: Posted

CFDA Numbers: 15.808

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FY 2027-2028 NESDIS Broad Agency Announcement (BAA)

Deadline: September 30, 2028

Opportunity Number: NOAA-NESDIS-NESDISPO-2027-33921

Agency: DOC NOAA - ERA Production

Open Date: October 13, 2026

Close Date: September 30, 2028

Status: Posted

CFDA Numbers: 11.015

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Accelerating Research and Development of Next Generation Vaccines against Malaria - a Model for Mosquito-Borne Diseases (R61/R33 Clinical Trial Not Allowed)

Deadline: February 11, 2027

Opportunity Number: RFA-AI-28-024

Agency: National Institutes of Health

Open Date: October 13, 2026

Close Date: February 11, 2027

Status: Posted

CFDA Numbers: 93.855

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Notice of Intent to Issue NOFO DE-FOA-0003649: Leveraging Domestic Infrastructure and Resources to Unleash Alternative Chemicals, Fuels and Feedstocks

Deadline: April 26, 2027

Opportunity Number: DE-FOA-0003648

Agency: Golden Field Office

Open Date: October 13, 2026

Close Date: April 26, 2027

Status: Posted

CFDA Numbers: 81.117

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Carcinogen Hazard Assessment Monographs Program (CHAMP) (R01 Clinical Trial Not Allowed)

Deadline: February 9, 2027

Opportunity Number: RFA-CA-28-013

Agency: National Institutes of Health

Open Date: October 9, 2026

Close Date: February 9, 2027

Status: Posted

CFDA Numbers: 93.399, 93.393, 93.396

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NIJ FY 2026 Research and Evaluation on School Safety

Deadline: November 23, 2026

Opportunity Number: O-NIJ-2026-172796

Agency: National Institute of Justice

Open Date: October 9, 2026

Close Date: November 23, 2026

Status: Posted

CFDA Numbers: 16.560

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Cellular Senescence Network (SenNet): SenNet Technology Projects (SenTecs) (UG3/UH3 Clinical Trial Not Allowed)

Deadline: November 23, 2026

Opportunity Number: RFA-RM-27-007

Agency: National Institutes of Health

Open Date: October 9, 2026

Close Date: November 23, 2026

Status: Posted

CFDA Numbers: 93.310

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NIAMS P30 Centers Program (P30 - Clinical Trial Not Allowed)

Deadline: March 1, 2029

Opportunity Number: RFA-AR-28-001

Agency: National Institutes of Health

Open Date: October 9, 2026

Close Date: March 1, 2029

Status: Posted

CFDA Numbers: 93.313, 93.846

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