Open for applications

Federal funding opportunity

Research Grants in Clinical Informatics (R01 Clinical Trial Optional)

National Institutes of Health

  • OpportunityPAR-26-042
  • Agency codeHHS-NIH11
  • CategoryDiscretionary (D)
927 days until applications close Mon, March 5, 2029
PostedFeb 11, 2026 ClosesMar 5, 2029
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Competitive proposals usually start 6+ weeks out.

$2.5M Est. program funding
$250,000 Award ceiling
$0 Award floor
10 Expected no. of awards

Program summary

Synopsis

The National Library of Medicine (NLM) seeks applications for innovative research in clinical informatics. The overarching goal of this forthcoming program is to catalyze the development and advancement of novel informatics methodologies that empower clinicians, patients, and the broader public to better understand, manage, and improve health and health care delivery. This NOFO will support research focused on the design, implementation, and evaluation of clinical informatics tools and methods that enable data-driven discovery, promote evidence-based decision-making, and support personalized and precision health care. Emphasis will be placed on domain-independent, scalable, and reusable/reproducible approaches for the discovery, analysis, organization, and management of health-related digital objects—including electronic health records (EHRs), clinical notes, imaging data, and patient-generated data. The aim is to transform raw and heterogeneous health data into actionable knowledge, to develop innovative tools, and to implement practical applications that can be generalized across multiple clinical settings and populations. Projects should demonstrate the potential to accelerate scientific insights, improve clinical workflows, and ultimately lead to improved health outcomes.

Timeline

Key dates

  • February 11, 2026
    Opportunity posted to grants.gov
  • August 21, 2026
    Today — 927 days of the window remain
  • March 5, 2029
    Applications close
  • May 4, 2029
    Opportunity archived

Who may apply

Eligibility

Eligible applicant types as published by the awarding agency:

  • For profit organizations other than small businesses
  • State governments
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Private institutions of higher education
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Special district governments
  • Small businesses
  • Public and State controlled institutions of higher education
  • Independent school districts
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • Native American tribal governments (Federally recognized)
  • County governments
  • City or township governments
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Public housing authorities/Indian housing authorities
Additional info on eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organizations) are eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.NIH will no longer issue awards (i.e., new, renewal, or non-competing continuation) to domestic or foreign entities that involve foreign subawards/subcontracts. All NIH-funded research involving foreign subawards/subcontracts must be submitted in response to a NOFO that is specifically designated for funded international collaborations. This new requirement was effective, May 1, 2025.Applications involving foreign subawards/subcontracts submitted in response to this NOFO will be deemed noncompliant and will not be considered for funding. This policy applies to all monetary international collaborations resulting in foreign subawards/subcontracts, however, it does not preclude unfunded international collaborations or foreign components, funding for foreign consultants, or procurement of unique equipment or supplies from foreign vendors.
Cost sharing or matching
Not required

Awarding agency

Additional information

Agency name
National Institutes of Health
Grantor contact
National Institutes of Health
301-402-2541
NLMProgram@nih.gov

Assistance listing

CFDA program(s)

  • 93.879 Medical Library Assistance

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