Open for applications

Federal funding opportunity

Development and Testing of a Multi-use Frameworks Playbook for Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) (U01 Clinical Trial Not Allowed)

National Institutes of Health

  • OpportunityRFA-RM-27-011
  • Agency codeHHS-NIH11
  • CategoryDiscretionary (D)
49 days until applications close Fri, October 9, 2026
PostedJun 30, 2026 ClosesOct 9, 2026
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Competitive proposals usually start 6+ weeks out.

$2M Est. program funding
$300,000 Award ceiling
N/a Award floor
5 Expected no. of awards

Program summary

Synopsis

The overarching goal of this notice of funding opportunity (NOFO) and its companion opportunities is to establish the Precision Medicine with AI: Integrating Imaging with Multimodal Data (PRIMED-AI) Program to support development of innovative, reliable, cost-effective, and sustainable multimodal AI-based clinical decision support (CDS) tools. PRIMED-AI CDS tools are based on the integration of clinical imaging with other types of multimodal health data to enhance care for patients with a wide range of health conditions. The PRIMED-AI Program seeks to catalyze the adoption of AI-based CDS tools into clinical workflows to enable novel personalized medicine strategies that address significant health challenges. The purpose of this NOFO is to solicit applications for the design, development, and preliminary validation of robust frameworks for the application of multimodal-artificial intelligence (AI) models for clinical use. Frameworks developed through these awards would populate a "playbook", defined as a collection of actionable guidelines, standardized protocols, and/or standard operating procedures (SOPs) for reliable and effective development and deployment of multimodal AI tools. It is expected that the frameworks delineated in this playbook will directly address PRIMED-AI objectives and needs, while also remaining flexible enough to enable sufficient extensibility and interoperability for use across a broad spectrum of multimodal biomedical AI applications, both internal and external to the PRIMED-AI Program.

Timeline

Key dates

  • June 30, 2026
    Opportunity posted to grants.gov
  • August 21, 2026
    Today — 49 days of the window remain
  • October 9, 2026
    Applications close
  • December 8, 2026
    Opportunity archived

Who may apply

Eligibility

Eligible applicant types as published by the awarding agency:

  • State governments
  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • Private institutions of higher education
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • Special district governments
  • Public and State controlled institutions of higher education
  • Independent school districts
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Small businesses
  • City or township governments
  • Public housing authorities/Indian housing authorities
  • County governments
  • Native American tribal governments (Federally recognized)
  • For profit organizations other than small businesses
Additional info on eligibility
Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Cost sharing or matching
Not required

Awarding agency

Additional information

Agency name
National Institutes of Health
Grantor contact
National Institutes of Health
301-402-2541
ODPRIMED-AI@od.nih.gov

Assistance listing

CFDA program(s)

  • 93.310 Trans-NIH Research Support

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