Open for applications

Federal funding opportunity

Cancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)

National Institutes of Health

  • OpportunityPAR-25-444
  • Agency codeHHS-NIH11
  • CategoryDiscretionary (D)
766 days until applications close Mon, September 25, 2028
PostedNov 26, 2025 ClosesSep 25, 2028
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Competitive proposals usually start 6+ weeks out.

N/a Est. program funding
N/a Award ceiling
N/a Award floor
N/a Expected no. of awards

Program summary

Synopsis

This Notice of Funding Opportunity (NOFO) invites applications for P30 Cancer Center Support Grants (CCSGs) to support NCI-Designated Cancer Centers. CCSGs support three types of Cancer Centers: 1) Comprehensive Cancer Centers, which demonstrate reasonable depth and breadth of research activities in each of three major areas: basic laboratory; clinical; and prevention, control and population-based research, and which have substantial transdisciplinary research that bridges these scientific areas; and 2) Clinical Cancer Centers, which are primarily focused on basic laboratory; clinical; and prevention, cancer control, and population-based research; or some combination of these areas, and 3) Basic Cancer Centers, which focus on basic laboratory research. The purpose of all types of NCI-Designated Cancer Centers is to capitalize on all institutional cancer research capabilities, integrating meritorious research into a single transdisciplinary research enterprise across all institutional boundaries. Cancer Centers supported through this NOFO are expected to serve as major sources of discovery of the nature of cancer and of development of more effective approaches to prevention, diagnosis, and therapy; to contribute significantly to the development of Shared Resources that support research; to collaborate and coordinate their research efforts with other NCI-funded programs and investigators; and to disseminate research findings for the benefit of the community.

Timeline

Key dates

  • November 26, 2025
    Opportunity posted to grants.gov
  • August 21, 2026
    Today — 766 days of the window remain
  • September 25, 2028
    Applications close
  • October 30, 2028
    Opportunity archived

Who may apply

Eligibility

Eligible applicant types as published by the awarding agency:

  • Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education
  • County governments
  • Native American tribal organizations (other than Federally recognized tribal governments)
  • Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education
  • City or township governments
  • Independent school districts
  • Private institutions of higher education
  • Small businesses
  • Public and State controlled institutions of higher education
  • For profit organizations other than small businesses
  • Native American tribal governments (Federally recognized)
  • Special district governments
  • Others (see text field entitled "Additional Information on Eligibility" for clarification)
  • State governments
Additional info on eligibility
Specific to this NOFO:For New (Type 1) applications, an applicant institution must have a funding base of $10,000,000 (Clinical Cancer Centers) or $6,000,000 (Basic Cancer Centers) in annual direct costs of NIH funding that is cancer-focused, as defined by the Research Condition and Disease Categorization (RCDC) system. Please contact the NCI Office of Cancer Centers (https://cancercenters.cancer.gov/) for assistance in determining the RCDC funding base.For Renewal (Type 2) applications, an applicant institution must have a funding base of at least $10,000,000 in annual direct costs of peer-reviewed, cancer-related funding. If the Cancer Center is an approved consortium of institutions, the funding base of the Center will be the sum of the funding bases of all participating institutions. However, funding (and other data) awarded to consortium partners may be included only if the partner has been previously evaluated in CCSG peer-review and approved by NCI.Example of NCI peer-reviewed mechanisms that may be included for determining eligibility to apply for a CCSG: DP1, DP2, R00, R01, R03, R15, R18, R21, R24, R25, R33, R35, R37, R41, R42, R50, R55, R56, P01, P20, P30s other than the CCSG, P50, SC1, SC2, U01, U10, U19, U24, U54, U56, UH2, UH3, UG3, T32, K and F series awards and N01s (excluding SEER and other N01s funding materials, services, or research resources). Cancer-relevant research funded by these mechanisms from other NIH Institutes may also be counted towards the minimum, as do cancer-relevant grants and contracts from the peer-reviewed funding sources listed in: https://cancercenters.cancer.gov/sites/default/files/PeerReviewFundingOrganizations.pdfNOTE: New (Type 1) applications cannot request evaluation for comprehensiveness status.Foreign Organizations/International CollaborationsNon-domestic (non-U.S.) Entities (Foreign Organization) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are not allowed.
Cost sharing or matching
Not required

Awarding agency

Additional information

Agency name
National Institutes of Health
Grantor contact
National Institutes of Health
301-402-2541
ncicenters-r@mail.nih.gov

Assistance listing

CFDA program(s)

  • 93.397 Cancer Centers Support Grants

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766 days is enough time — if you start now.

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