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HeartShare 2.0: Refining Heart Failure Subtypes and Treatment Targets for Personalized Clinical Trials - Clinical Trial Center and Clinical Centers (U01 Clinical Trial Optional)
National Institutes of Health
RFA-HL-27-008
HHS-NIH11
General Information
Est. Program Funding:
Closing Date:
Expected No. of Awards
Award Ceiling
Opportunity Number:
RFA-HL-27-008
Owning Agency:
HHS-NIH11
Opportunity Category:
Discretionary (D)
Synopsis
| The purpose of this Notice of Funding Opportunity (NOFO) is to solicit applications for a new Clinical Trial Center (CTC) and up to seven Clinical Centers (CCs) for the HeartShare 2.0 program. The CTC will coordinate precision clinical trial activities focused on heart failure with preserved ejection fraction (HFpEF), including master protocol development, project management, recruitment oversight, performance milestones, and scientific conduct of trials. The CCs will recruit and retain heart failure patients and controls. The CCs will participate in all aspects of conducting a deep phenotyping protocol and longitudinal follow-up of HFpEF patients; obtaining tissue biopsies; and recruiting patients for future clinical trials.Eligible applicants may submit proposals for either the CTC or CC, but must have different PIs. Each application should include CTC or CC as part of their project title.Companion NOFO for RFA-HL-27-009 will support a Data Translation Center (DTC) for overall coordination of the HeartShare program. | |
| Response Date | Jul 09, 2026 12:00:00 AM EDT |
| Posting Date | May 19, 2026 12:00:00 AM EDT |
| Archive Date | Sep 07, 2026 12:00:00 AM EDT |
| Award Ceiling | 500,000 |
| Award Floor | N/a |
| Cost Sharing | No |
Eligibility
| Eligible Applicants | Public housing authorities/Indian housing authorities, Native American tribal governments (Federally recognized), Private institutions of higher education, Independent school districts, Native American tribal organizations (other than Federally recognized tribal governments), City or township governments, Public and State controlled institutions of higher education, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, For profit organizations other than small businesses, State governments, County governments, Special district governments, Small businesses, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification) |
| Additional Info on Eligibility: | Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed. |
Additional Information
| Agency Name | National Institutes of Health |
| Link to Additional Information: | N/a |
| Grantor Contact Information: |
If you have difficulty accessing the full announcement electronically, please contact:
GrantSolutions Help Desk Phone: 301-402-2541 |
CFDA Program(s)
- 93.837: Cardiovascular Diseases Research
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