The Office of Cooperative Threat Reduction (CTR) is a key component of the Department’s and ACN’s efforts to advance the Administration’s top national security and foreign policy objectives in a cost-effective and impactful manner. CTR uses programming and training with foreign partners to advance President Trump’s America First Investment Policy (NSPM-3) and America’s AI Action plan by disrupting the Chinese Communist Party’s (CCP) exploitation of critical U.S. intellectual property (IP) and dual-use technologies, including AI, biotechnologies, quantum, semiconductor, and space technologies, through research security, cybersecurity and IP protection training. As the programmatic lead for the Foundational Infrastructure for the Responsible Use of Small Modular Reactor [SMR] Technology (FIRST) program, CTR implements Section 8(e) of EO 14299 on Deploying Advanced Nuclear Reactor Technologies for National Security by helping U.S. vendors deploy secure, safe U.S. SMRs to strategic regions, including Latin America, the Indo-Pacific, and the Middle East, to outcompete strategic competitors for decades-long partnerships, generating multi-billion dollar deals for U.S. companies and creating thousands of American jobs. CTR implements maximum pressure on Iran (NSPM-2), by training foreign partner countries to implement U.S. sanctions on Iran’s nuclear weapons and ballistic missile programs, and disrupts proliferation networks tied to the CCP, DPRK, and Russia that undermine U.S. interests.