Synopsis

Invasive surgical procedures in humans offer the unique opportunity to intracranially record and stimulate neuronal activity within precisely localized brain structures, enabling high-impact human neuroscience investigations. This NOFO seeks exploratory research projects, from newly formed or established multi-disciplinary teams, to understand how dynamic activity of single cells and ensembles of neurons in spatially organized networks gives rise to the internal states we experience as sensations, perceptions, emotions, thoughts, and memories, and to observable motor and social behaviors. The research should be proposed as exploratory research and planning activities to establish feasibility and early-stage development that, if successful, would support, enable, and/or lay the groundwork for a potential, subsequent research project grant applications using invasive neural recording and stimulation technologies in the human brain. Projects should maximize opportunities to conduct innovative in vivo human neuroscience research made available by direct access to the brain from invasive surgical procedures. Projects should employ approaches guided by specified theoretical constructs and by quantitative, mechanistic models where appropriate. Recipients will join a consortium working group, coordinated by the NIH, to identify consensus standards of practice, including neuroethical considerations, to collect and provide data for ancillary studies, and to aggregate and standardize data for dissemination among the wider scientific community.
Response Date	Feb 11, 2027 12:00:00 AM EST
Posting Date	May 04, 2026 12:00:00 AM EDT
Archive Date	Apr 12, 2027 12:00:00 AM EDT
Award Ceiling	700,000
Award Floor	N/a
Cost Sharing	No

Eligibility

Eligible Applicants

Public and State controlled institutions of higher education, Public housing authorities/Indian housing authorities, Small businesses, County governments, State governments, Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Independent school districts, Native American tribal organizations (other than Federally recognized tribal governments), Native American tribal governments (Federally recognized), City or township governments, Private institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Special district governments, For profit organizations other than small businesses

Additional Info on Eligibility:

Refer to Section III. Eligibility Information in the NOFO for additional information on eligibility.Foreign Organizations/International Collaborations:Non-domestic (non-U.S.) Entities (Foreign Organizations) are not eligible to apply.Non-domestic (non-U.S.) components of U.S. Organizations are not eligible to apply.Foreign components, as defined in the NIH Grants Policy Statement, are allowed.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	N/a
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

• 93.173: Research Related to Deafness and Communication Disorders
• 93.213: Research and Training in Complementary and Integrative Health
• 93.242: Mental Health Research Grants
• 93.273: Alcohol Research Programs
• 93.279: Drug Use and Addiction Research Programs
• 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health
• 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders
• 93.865: Child Health and Human Development Extramural Research
• 93.866: Aging Research
• 93.867: Vision Research