Synopsis

The Theories, Models and Methods (TMM) initiative will support the development of computational tools for understanding dynamic brain circuits that are made broadly accessible to the greater research community. This program supports applications focused on tool building and dissemination in the domain of theories about neural circuit mechanisms, models of circuit structure and function, and/or computational methods of analysis spanning across scales from neurons to behavior. The development of novel theories, computational models and methods for understanding brain function will help characterize fundamental principles of brain function and organization, characterize cellular and circuit-level neural computations over time in different regions, and understand how interactions of multiple brain circuits enable flexible behaviors and contribute to brain-wide neural dynamics. These tools will be critical for developing treatments such as closed loop systems for brain disorders including Parkinsons disease and major depressive disorder.
Response Date	Nov 08, 2027 12:00:00 AM EST
Posting Date	Sep 16, 2025 12:00:00 AM EDT
Archive Date	Dec 14, 2027 12:00:00 AM EST
Award Ceiling	N/a
Award Floor	N/a
Cost Sharing	No

Eligibility

Eligible Applicants

Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, County governments, Special district governments, Private institutions of higher education, Public housing authorities/Indian housing authorities, Independent school districts, Public and State controlled institutions of higher education, Others (see text field entitled "Additional Information on Eligibility" for clarification), Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), State governments, City or township governments, For profit organizations other than small businesses, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Small businesses

Additional Info on Eligibility:

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	https://grants.nih.gov/grants/guide/rfa-files/RFA-DA-27-004.html
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

• 93.173: Research Related to Deafness and Communication Disorders
• 93.213: Research and Training in Complementary and Integrative Health
• 93.242: Mental Health Research Grants
• 93.273: Alcohol Research Programs
• 93.279: Drug Use and Addiction Research Programs
• 93.286: Discovery and Applied Research for Technological Innovations to Improve Human Health
• 93.372: 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies
• 93.853: Extramural Research Programs in the Neurosciences and Neurological Disorders
• 93.865: Child Health and Human Development Extramural Research
• 93.866: Aging Research
• 93.867: Vision Research