Synopsis

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs. This includes preclinical and clinical research studies that will have high impact and quickly yield the necessary results to advance candidate interventions closer to regulatory approval or clinical adoption. This NOFO will utilize the UG3/UH3 activity code.
Response Date	Aug 21, 2028 12:00:00 AM EDT
Posting Date	Sep 10, 2025 12:00:00 AM EDT
Archive Date	Sep 26, 2028 12:00:00 AM EDT
Award Ceiling	3,000,000
Award Floor	N/a
Cost Sharing	No

Eligibility

Eligible Applicants

Others (see text field entitled "Additional Information on Eligibility" for clarification), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, Independent school districts, Public and State controlled institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Small businesses, City or township governments, State governments, Native American tribal governments (Federally recognized), County governments, Native American tribal organizations (other than Federally recognized tribal governments), For profit organizations other than small businesses, Public housing authorities/Indian housing authorities, Special district governments

Additional Info on Eligibility:

Other Eligible Applicants include the following: Eligible Agencies of the Federal Government; Faith-based or Community-based Organizations; Indian/Native American Tribal Governments (Other than Federally Recognized); Non-domestic (non-U.S.) Entities (Foreign Organizations); Regional Organizations; U.S. Territory or Possession.

Additional Information

Agency Name	National Institutes of Health
Link to Additional Information:	https://grants.nih.gov/grants/guide/pa-files/PAR-25-446.html
Grantor Contact Information:	If you have difficulty accessing the full announcement electronically, please contact: GrantSolutions Help Desk Phone: 301-402-2541

CFDA Program(s)

• 93.279: Drug Use and Addiction Research Programs